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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PEX1 All Species: 10.61
Human Site: S506 Identified Species: 14.58
UniProt: O43933 Number Species: 16
    Phosphosite Substitution
    Charge Score: -0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O43933 NP_000457.1 1283 142867 S506 F S L S I V H S W E K E K D K
Chimpanzee Pan troglodytes XP_519198 1283 142803 S506 F S L S I V H S W E K E K D K
Rhesus Macaque Macaca mulatta XP_001101055 1278 142022 S504 F S L S I V H S W E K E K D K
Dog Lupus familis XP_532459 1267 140567 H490 E F S L N V V H S W E K D K E
Cat Felis silvestris
Mouse Mus musculus Q5BL07 1284 141409 E507 L S T V H S Q E K E K E E G K
Rat Rattus norvegicus P46462 806 89330 R113 P D V K Y G K R I H V L P I D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001520628 1178 126535 E471 L S A V Q P P E P E P S G E E
Chicken Gallus gallus XP_418655 1290 143066 S514 M H T E E D K S E N T F I L S
Frog Xenopus laevis P23787 805 89193 K112 C P D V K Y G K R V H V L P I
Zebra Danio Brachydanio rerio Q7ZU99 806 89405 R113 P D V K Y G K R I H V L P I D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q7KN62 801 88841 G108 S C P D V K Y G K R V R I L P
Honey Bee Apis mellifera XP_397107 1069 120490 F376 V P S S L E L F S W R D S V S
Nematode Worm Caenorhab. elegans P54812 810 89622 K117 S A Q L E Y G K R V H V L P I
Sea Urchin Strong. purpuratus XP_797089 1508 166130 L660 S T K E S Y F L L H P F V T R
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SCN8 815 90322 L122 Y G N R V H I L P L D D T I E
Baker's Yeast Sacchar. cerevisiae P24004 1043 117258 L350 S G D Q Y S K L L G G S L L T
Red Bread Mold Neurospora crassa Q7SGP2 1381 148356 T556 V I L Q H V R T P T A V E R D
Conservation
Percent
Protein Identity: 100 99.6 92.8 86.4 N.A. 82 23.3 N.A. 52.4 62.4 22.9 22.8 N.A. 23.6 27.6 22.1 35.2
Protein Similarity: 100 100 94.9 92 N.A. 89.5 39.2 N.A. 66 77.6 38.6 39 N.A. 37.6 46.7 38.4 53.2
P-Site Identity: 100 100 100 6.6 N.A. 33.3 0 N.A. 13.3 6.6 0 0 N.A. 0 6.6 0 0
P-Site Similarity: 100 100 100 26.6 N.A. 40 6.6 N.A. 26.6 6.6 0 6.6 N.A. 13.3 26.6 6.6 13.3
Percent
Protein Identity: N.A. N.A. N.A. 23.5 25.7 21.4
Protein Similarity: N.A. N.A. N.A. 38.5 45.2 40.9
P-Site Identity: N.A. N.A. N.A. 0 0 13.3
P-Site Similarity: N.A. N.A. N.A. 26.6 0 26.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 6 6 0 0 0 0 0 0 0 6 0 0 0 0 % A
% Cys: 6 6 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 12 12 6 0 6 0 0 0 0 6 12 6 18 18 % D
% Glu: 6 0 0 12 12 6 0 12 6 30 6 24 12 6 18 % E
% Phe: 18 6 0 0 0 0 6 6 0 0 0 12 0 0 0 % F
% Gly: 0 12 0 0 0 12 12 6 0 6 6 0 6 6 0 % G
% His: 0 6 0 0 12 6 18 6 0 18 12 0 0 0 0 % H
% Ile: 0 6 0 0 18 0 6 0 12 0 0 0 12 18 12 % I
% Lys: 0 0 6 12 6 6 24 12 12 0 24 6 18 6 24 % K
% Leu: 12 0 24 12 6 0 6 18 12 6 0 12 18 18 0 % L
% Met: 6 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 6 0 6 0 0 0 0 6 0 0 0 0 0 % N
% Pro: 12 12 6 0 0 6 6 0 18 0 12 0 12 12 6 % P
% Gln: 0 0 6 12 6 0 6 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 6 0 0 6 12 12 6 6 6 0 6 6 % R
% Ser: 24 30 12 24 6 12 0 24 12 0 0 12 6 0 12 % S
% Thr: 0 6 12 0 0 0 0 6 0 6 6 0 6 6 6 % T
% Val: 12 0 12 18 12 30 6 0 0 12 18 18 6 6 0 % V
% Trp: 0 0 0 0 0 0 0 0 18 12 0 0 0 0 0 % W
% Tyr: 6 0 0 0 18 18 6 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _